When it comes to creating responsive layouts, CSS Grid and Flexbox are two powerful tools in a developer’s arsenal. Flexbox is ideal for one-dimensional layouts, like rows or columns, and is perfect for aligning items along a single axis. On the other hand, CSS Grid excels at two-dimensional layouts, giving developers more control over both rows and columns simultaneously. The choice between them depends on the specific layout needs of your project, and understanding their strengths will help you create more flexible and maintainable designs.